Cytogenetics FISH tests

 

Neoplasm

Cytogenetic abnormality

Genes targeted, if known

Acute lymphoblastic leukaemia

t(9;22)

BCR-ABL1

t(12;21)

ETV6-RUNX1

11q23

MLL

t(1;19)

TCF3 (E2A)

9p deletion

CDKN2A (P16)

6q deletion

MYB

Acute myeloid leukaemia

t(8;21)

RUNX1-RUNX1T1

t(15;17)

PML-RARA

inv(16)

CBFB

11q23

MLL

trisomy 8

CEP8

3q26

MECOM (EVI1)

Chronic myeloid leukaemia

t(9;22)

BCR-ABL1

Non-Hodgkin lymphoma

t(8;14)

IGH-MYC

14q32

IGH

t(11;14)

IGH-CCND1

t(14;18)

IGH-BCL2

t(2;5)

NPM-ALK

3q27

BCL6

8q24

MYC

2p12

IGK

22q11.2

IGL

Chronic lymphocytic leukaemia

11q22-23 deletion

ATM

trisomy 12

CEP12

13q deletion

13q14.3

17p13 deletion

TP53

Myelodysplasia

5/5q

 

7/7q

 

trisomy 8

 

20q

 

3q26

MECOM (EVI1)

T-cell malignancies

1p32

STIL/TAL1

5q35

TLX3

14q11

TRA/TRD

7q34

TRB

9p21

CDKN2A

Multiple myeloma

t(11 ;14)

IGH-CCND1

t(4 ;14)

IGH-FGFR3

t(14;16)

IGH-MAF

17p deletion

TP53

13q deletion (13q14.3)

1q amplification / 1p deletion

CSK1B/CDKN2C

Myeloproliferative neoplasms

4q12 deletion

FIP1L1-PDGFRA

5q33

PDGFRB

8p12

FGFR