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Bone marrow sampling guidance (including MRD)

Guidance on bone marrow aspirate and trephine sampling requirements, including disease-specific pathways and MRD follow-up.

Sampling by clinical indication

Acute Leukaemia (AML or ALL)

• At diagnosis/relapse of acute leukaemia (AML or ALL) or pancytopenia of unknown cause

• AML follow-up after treatment (including MRD)

• ALL follow-up after treatment (including MRD)

Myeloma or Lymphoma

MPN (including CML), MDS, or unexplained cytopenia

Quick reference

• Summary of sample requirements

• Bone marrow biopsy demonstration (video)

• Useful resources